Dr J was interested in use of clays for pulling heavy metals out of his patients. I started out totally clueless about clays and other binders of toxins. It has been quite the journey. Heavy metal contamination seems to be a problem with the clays. Dr J decided to go with activated carbon for his patients. I am very eager to work with anyone who wants promote the safe use of clays for detox or just general health.
Zeolite, mostly clinoptilolite
- Zeolite sum covers the sub classes of these auminasilicates. Some are cancer promoting, others are therapeutic.
- Clinoptilolite decreases tight junction protein ZO-1 in the feces of human endurance atheletes. In other words, clinoptiloite strengthens the GI barrier when our blood flow that should be going to our GI tract is going to our exercising muscles.
- The silica part seems to activate T cells.
- Amine binding zeolites discusses binding of serotonin and histamine. The gut is a major source of serotonin/5-HT. Polyamines cadaverine and putrescine in cat urine and feces may be absorbed by clays too.
- Klinobind is a post about use of a clinoptilolite clay to bind toxins from Mexican smokers. What makes this study truly remarkable is that the authors gave the clay before the first morning meal. The concept is pure genius.
- CLinoptilolite continued (in cows!) examines a Croatian study in bovines. The authos dive deep into metabolic changes in amino acids and short chain fatty acids Safety parameters are also addressed. We tried to import this material but eventually gave up.
- GPR109a is a potential receptor β-hydroxybutyrate and other metabolites that are increased in cows fed Vibrosorb Croatian clinoptilolite.
- Clinoptilolite and Butyrate contains an great protocol for making the stuff, and suggestion that the combo improves many aspects of small intestine health in broiler chicks.
- Avian flu and zeolite explores a Polish study that tested the hypothesis that a home mined zeolite could improve the bone strength and gut integrity of chickens. Strong barrier function means less spillage o pathogens at the slaughter house and spread of disease.
- PMA processed clinoptilolite has been compared with colloidal silica. Panaceo Mechanically Activated zeolite uses kinetic energy to add surface charges. Addition of medical oxygen is also involved in the PMA process. The authors looked at heavy metal binding and whether material gets into the test rats.
- Philliposite clay had a small impact on the intestinal microbiome of these dogs eating an almost human diet.
- Fulvic acid and zeolite clays, should they be taken together?
- Butyrate and clinoptilolite is used a feed supplement for chickens…the mixture of a gut health clay and a gut healthy short chain fatty acid.
The bentonites/montmorillonites
This alumina silicate minreal is of volcanic origin and very porous. The montmorillonites, with calcium or sodium counter ions, are generally considered to be purer forms of benonite.
- montmorillonite and aflatoxin explores use of Montana mined montmorillonite taken by humans with meals prone to contain food contaminated with aflatoxin. This post explores trials in southern Texas of the United States and two African countries.
- Montmorillonite and charcoal compares the heavy metal binding capacity (As, Pb, Hg, and Cd) at stomach and small intestine pH. The winner is medical activated carbon (charcoal).
- montmorillonite binds paraquat and glyphosate This study was performed on the Texas Entero-sorbant montmorillonite mined in Montana, USA.
- Glyphosate and lipids describes how this herbicide can mess up our lipids!
- heavy metal chemistry challenges the paraquat and glyphosate models of binding. Metal oxide groups bind to oxyanions via d-shell electrons
Biochar, activated carbon, Buckeyball…
It is not the pure carbon structures that bind toxins but the oxygen groups that are there along for the ride.
- Structure of non-graphene carbon gets into the different typs of carbon bonds.
- The C60 post is also about activated carbon, that is used for detox. There are some very chemical properties of all of these agents.
- Activated Carbon is a blog about a colonic delivery form of activated carbon, DAV132 that prevents oral antibiotics from messing with our intestinal microbiome.
- DIY activated carbon explores the beauty in electronmicroscope structures of activated carbons from plant wastes that are not wood or coconut shell.
- Pecan nut shell biochar is about activated carbon/biochar made from pecan shells. I was thinking this would be a good way to have a home grown low heavy metal source of activated carbon
Other heavy metal chelators
- Clearing aluminum examines use of silica to bind alumina. It briefly discusses size issues of using traditional transition metal chelators for aluminum,
- Alumina poisoning explores why a metal oxide, alumina, may be toxic to the brain. It is used as an adjuvant in vaccines after all. Brief mention is made of beryllium hypersensitivity. Alumina binding peptides are also introduced.
- MIF1, ovalbumin, the BBB: This post had started off exploring ways of chelating aluminum out of the brains of autistic kids. The first two things we came up with were silica and egg white peptides. We then decided to go back to curing the intestinal, and maybe the oral, microbiome. MIFis macrophage migration inhibitory factor.
- Emeramide is about a mercury chelator
- aquaporins is an almost abandoned post about transport of metaloids though a channel that used to be for water and glycerol.
- DMSA and EDTA heavy metal chelation compares Garry Gordon’s EDTA method with mercury chelation with DMSA.
- Chelation therapies is about lipoic acid and DMSA. This post also covers ways in which metals are excreted naturally.
- Other Detox Methods covers Dan Pursor’s specialized glutathione and sweating via exercise or saunas to sweat out heavy metals.
- Clearing aluminum We have been looking at DMSA and EDTA for the elimination of lead (Pb) This post will weakly acknowledge a South Korean study, [1] Pb is not Al! While both are “basic metals”, they are different! Auaporin aluminum channels are introduced.
- aquaporins is an elaboration on the previous post on metalloid transport.
- GSH and Hg detox is a rather involved post addessing the Bridge’s Lab hypothesis that mercury is removed from our bodies by binding to albumin. The albumin is digested into peptides in lysosomes, handed off to glutathione, eliminated…
- Albumin binding proteins… Where are the proteins that transport mercury binding albumin to lysosomes and so on? It appears that denatured albumin is handled differently than native albumin.
- DMSA and ALA transporters covers OAT1, MRP2, and the Na+ multi-vitamin transporter.
- Detox agents bind nutrients. Clays and activated carbon bind water and fat soluble vitamins as well as amino acids. These agents are used as animal feed additives to bind mycotoxins.
Miscellaneous binding posts
- Chitosan This loops back to the post on P gingivalis being induced by cortisol. The periodontal delivery paper [2] didn’t seem to be that great. It is recommended to go directly to the 3rd reference. The take home of the chitosan and bile acid paper is that chitosan might bind cortisol too.
- Mycotoxin binders bind nutrients addresses the binding of amino acids and vitamins to the clays and activated carbon used in feed supplements.