This post started as a continuation on a previous post on clearing aluminum using silica. The question was asked as how silica is transported in our bodies. The answer is by aquaporins. Silicates can induce the exression these aquaporins. If alumina can traverse these channels, is this a way for alumina to get out of intracellular places? The other question that needs to be answered is if alumina is associated with oxygen, bound to thiols, or what? Some of these references hint that any alumina silicates that are formed might interact with these multipurpose channels. Reference  is one of many warnings that silicates are irritants even if they might bump up the expression of aquaporins.
An excellent Aquaporin review 
Aquaporins are found in all major domains of life on this planet from bacteria to plants, and animals.  They are multi purpose transporters for urea, glycerol, H2O2, and metaloid oxides.  The corresponding author of this review was emailed and asked if aquaporins can transport alumina.
Can auaporins transport alumina? Dr Barry Rosen was contacted. Dr Rosen thought it might be possible with teh caviate that his professional expertise and chemistry knowledge was with As(OH)3, areseic.
Good luck, Barry Rosen”
- Hao X, Wang H, Liu W, Liu S, Peng Z, Sun Y, Zhao J, Jiang Q, Liu H. Enhanced expression levels of aquaporin-1 and aquaporin-4 in A549 cells exposed to silicon dioxide. Mol Med Rep. 2016 Sep;14(3):2101-6. PMC free article
- Mukhopadhyay R, Bhattacharjee H, Rosen BP. Aquaglyceroporins: generalized metalloid channels. Biochim Biophys Acta. 2014 May;1840(5):1583-91. PMC free article
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