PEMF

PEMF and bone healing

PEMF has been examined for 40+ years as a means of helping bones heal themselves. The Magnawave Semi-10 uses frequencies between 1-20 Hz depending on the setting. The magnetic field has a max of 4,700 G at the highest setting. As the setting increases the frequency decreases and the magnetic field increases. A table from a Wang 2024 review of studies dating back to 1983 is expanded upon. Many studies used higher frequency bursts at low frequency intervals. The Cho Lab of South Korea. This lab has examined in interplay between magnetic field intensity and frequency in the differentiation of bone resorbing osteoclasts: 7.5 Hz is pro osteoclast and 45 Hz is anti-osteoclast in cultured cells. The featured image from Libre Texts brings home the blood flow in bone growth. Libre Texts also emphasizes that bone remodeling, resorption and regrowth occur in regions of stress and muscle action. The Cleveland Clinic also reminds us of the importance of both processes for healthy bones. We need to remember that PEMF can improve blood flow in the general circulation and probably in bone.

PEMF

PEMF for inflammation

Professional organizations like MagnaWave and AOPP claim that PEMF relieves inflammation. How this happens is largely unknown. The featured image came from a review on how charges in solution line up on surface charges. from metals, to metal oxides, to ion exchange membranes, and finally biological membranes. Some images of skin and bone joints are shown. Are these like ion exchange membranes that benefit from stirring up to aid in detoxification? What about counter ions around our phospholipid cell membranes? What are the other hypotheses concerning how PEMF reduces inflammation?

PEMF

Myoblasts ERK PEMF

The goal of this post was to come to some sort of understanding as to who, why, and if we even care if pulsed electromagnetic frequency (PEMF) therapy increases phosphorylation (activation of extracellular signal regulated kinases (ERK). Kinases are enzymes that attach phosphate groups to the -OH groups of serine, threonine, and tyrosine amino acid side chains. This sequential tagging is called signal transduction. This matter is being investigated because if a dog is being treated with PEMF to improve bone and muscle health of an injured limb, what happens if the dog has cardiac hypertrophy? Sure, preventing muscle atrophy would be good, but we don't want the dog's heart increasing in mass more. In this investigation, it was included that ERK phosphorylation is increased in PEMF of cultured myoblasts [1] and electrical muscle stimulation in a rat hindlimb unloaded model. [2] On the other hand, PEMF fires through PI3 kinase in serum deprived osteoblasts.