clays and binders, gut health, microbiomes, short chain fatty acids


This post is about GPR109a and the response to LPS. It is a direct full circle to the post called Clinoptilolite that describes a decrease in the tight junction protein ZO-1 in the feces of human endurance atheletes. CLinoptilolite decreases the loss of barrier function. Clinoptilolite cont addresses a metabolomics study demonstrating changes in β-hydroxybutyrate and other metabolites that could be ligands for GPR109a in dairy cows

clays and binders, gut health

clinoptilolite and T cells

This post is a melding of two related papers A 1994 Japanese paper shows activation of T cells by what they call crysotile.  Cystotile is the silicate we commonly call asbestos, [1] A 2004 Croatian paper describes a clinical trial of clinoptilolite, a mineral that contains silica and alumina, on immune cells in immunocompromised participants. [2]

clays and binders, gut health, short chain fatty acids

Clinoptilolite Cont

This investigation was conducted by the School of Veterinary Medicine at the University of Zagreb, Croatia. This study used a total of 16 high-yielding Holstein-Friesian dairy cows averaging 680 ± 30 kg of body weight, between 2–7 years of age. The cows were fed a control diet of haylage, corn silage, and a complete feed mixture with 19% of crude protein. The dietary forage-to-concentrate ratio was5:25 and 60:40

clays and binders, gut health, microbiomes


This post is about a clinical trial of clinoptilolite zeolite clay to prevent aspects of leaky gut in endurance athletes. [1] Leaky gut, loss of intestinal barrier function, is a problem with endurance athletes who experience transient intestinal ischemia. [2] A related study demonstrated that curcumic, the active compound in turmeric root extracts, protects against… Continue reading clinoptilolite