This post points to Nrf2 as the mediator of α-LA protection against As, Hg, and Cd toxicity and GSH synthesis as an important part of the protection.
Regarding detox, transporters (and carriers/chelators) are the key. There are so many steps and each one needs to be looked at closely. . 0. Background Lipoic acid: Na+ Multi vitamin transporter The SMVT was considered a transporter of LA due to competition with substrates biotin and pantothenic acid. The need for LA transport is fuzzy… Continue reading DMSA and ALA transporters