This post explores how how a cupric nicotinic acid chelate might enhance macrophage phagocytosis of Gram negative bacteria. The process is really not so simple after all. At each step we may ask the question, "Is copper a cofactor in proteins involved in the macrophage response to LPS?" Copper binds to LPS We have extremely… Continue reading Copper and innate immune system
Moringa seeds are a Food According to Romuald Saa and others at the University of Ngaounderein Cameroon, moringa is a food capable of providing a source of protein and other nutrients in regions of Sub Saharan Africa. Saa and coauthors stated a warning that unprocessed crude seeds of Moringa oleifera seeds are very toxic due… Continue reading What is Moringa?
Targeting KRAS in pancreatic cancer The Kirsten rat adenosarcoma (KRAS) gene codes for a member of the RAS small GTP binding protein family. RAS small G proteins are activated when they interact with growth factor bound receptors. They are inactivated when they interact with G=protein associated proteins (GAP). GAPs activate hydrolysis of GTP to GDP. … Continue reading novel pancreatic cancer treatment
This is a continuation of a previous post comparing the cholesterol lowering abilities of a statin and a Ganaderma lucidium extract. Effect of experimental diets on intestinal phyla and the Lactobacillus genus This is figure 6 in the Meneses 2016 publication. Liberty was taken to add phylogenic classification of five members of the human… Continue reading Ganaderma lucidium and gut microbiome
A multi-center FGF21 clinical trial is conducted in the area for the use of a modified fibroblast growth factor 21 for the treatment of NASH with fibrosis. What is NASH? What is fibroblast growth factor 21? Fibroblast Growth Factor 21 (FGF21) is secreted by hepatocytes. FGF21 stimulates glucose uptake in differentiated adipocytes. The FGF21 Wikipedia… Continue reading FGF21 and NASH