Flavors in e-cigarettes appear to have biological affects of their own even though they are FDA approved for food.
This post explores how how a cupric nicotinic acid chelate might enhance macrophage phagocytosis of Gram negative bacteria. The process is really not so simple after all. At each step we may ask the question, "Is copper a cofactor in proteins involved in the macrophage response to LPS?" Copper binds to LPS We have extremely… Continue reading Copper and innate immune system
Targeting KRAS in pancreatic cancer The Kirsten rat adenosarcoma (KRAS) gene codes for a member of the RAS small GTP binding protein family. RAS small G proteins are activated when they interact with growth factor bound receptors. They are inactivated when they interact with G=protein associated proteins (GAP). GAPs activate hydrolysis of GTP to GDP. … Continue reading novel pancreatic cancer treatment
A multi-center FGF21 clinical trial is conducted in the area for the use of a modified fibroblast growth factor 21 for the treatment of NASH with fibrosis. What is NASH? What is fibroblast growth factor 21? Fibroblast Growth Factor 21 (FGF21) is secreted by hepatocytes. FGF21 stimulates glucose uptake in differentiated adipocytes. The FGF21 Wikipedia… Continue reading FGF21 and NASH
Larrea tridentata, the creosote bush of the US Southwest, goes by many names: chaparral, greasewood, gobernadora, and hediondilla. I've been told that these bushes are responsible for the sweet smell that fills the air after monsoon storms. A good overview in 2010 Lü and coworkers at Baylor College of Medicine Houston published a short review… Continue reading NDGA and diet induced obesity