Uncategorized

novel pancreatic cancer treatment

Targeting KRAS in pancreatic cancer The Kirsten rat adenosarcoma (KRAS) gene codes for a member of the RAS small GTP binding protein family.  RAS small G proteins are activated when they interact with growth factor bound receptors.  They are inactivated when they interact with G=protein associated proteins (GAP).  GAPs activate hydrolysis of  GTP to GDP. … Continue reading novel pancreatic cancer treatment

fat burning, liver disease, NASH, Uncategorized

FGF21 and NASH

A multi-center FGF21 clinical trial is conducted in the area for the use of a modified fibroblast growth factor 21 for the treatment of NASH  with fibrosis.  What is NASH? What is fibroblast growth factor 21? Fibroblast Growth Factor 21 (FGF21) is secreted by hepatocytes.  FGF21 stimulates glucose uptake in differentiated adipocytes.  The FGF21 Wikipedia… Continue reading FGF21 and NASH

fat burning, type 2 diabetes, Uncategorized

NDGA and diet induced obesity

Larrea tridentata, the creosote bush of the US Southwest, goes by many names:  chaparral, greasewood,  gobernadora, and  hediondilla. I've been told that these bushes are responsible for the sweet smell that fills the air after monsoon storms. A good overview in 2010 Lü and coworkers at Baylor College of Medicine Houston published a short review… Continue reading NDGA and diet induced obesity