Does Band 3 of red blood cells transport sulfate and vitamin B6 under physiological conditions? Even though we've known about this for many decades, The clinical significance is not well known though it might be fairly easy to measure.
Category: thiols and sulfur
B6 and transsulfuration
There is a connection between a sulfur salvage pathway enzyme S-adenosyl homocysteine hydrolase and vitamin B6. Both might be impacted in autism spectrum of disorders. Perhaps there is a connection in all of us. This post is what happens when one sits down with a collection of publications and asks, "How are these papers related?"… Continue reading B6 and transsulfuration
Renal Transporters
What other transporters are working with NaS1 and SAT1? NaS1 also known as slc13a1 is the sodium coupled sulfate transporter thatdepends n the electro chemical gradient of Na+ . SAT1 is a passive sulfate anion exchanger that is also known as Slc26a1. The goal was to figure out which part of the renal tubule these… Continue reading Renal Transporters
H2S Production
This post was inspired by a review on fatty liver disease that listed four enzymes responsible for H2S production. Transsulfuration Pathway to H2S in NAFLD [1]Cystathionine gamma-lyase (CSE) Cystathionine beta-synthase (CBS) CBS in Down's Syndrome [2]CBS regulation by glutathionylation [3]EC 2.6.1.3: cysteine transaminase, cysteine aminotransferase (CAT)found in bovine brain, [4]CAT does not act alone [5]3-mercaptopyruvate… Continue reading H2S Production
sulfate testing hacks
Biosystem's Sulfate test is meant for 96 well plates... This link says that it is good for plasma and urine. It is a wonderful 96 well assay that requires a plate reader. This is the way to go if one wants to run several dozen tests at a time. It requires the allotment of wells… Continue reading sulfate testing hacks