All roads lead to acetylation and/or AMPK phosphorylation. This post summarizes previous posts exploring dietary agents and pharmaceuticals that might impact lysosome function. In the end, all roads lead to one or more sirtuin(s) and/or AMPK activation. We are left with a philosophical question: are these compound direct agonists or allosteric modulators that might make an enzyme more or less sensitive to the actual agonist. The implication is that proper nutraceuticals/pharmaceuticals may make our bodies more sensitive to our endogenous signalling.
Category: lysosomes
5-amino-1MQ
Nicotinamide N-methyltransferase, NNMT, atalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methyl nicotinamide. The methyl group (starred in the featured image) makes it easier to lose a valuable source of NAD+ in the urine. While NNMT may be a good way of preventing excess buildup of niacin, aka vitamin B3, there may be other reasons why we do not want to limit our body's coffers of NAD+. This journey was inspired by JayCampbell.com [1]. Could 5-amino-1MQ be a good supplement for non-body builders? The implications may impact epigenetics and other methylation reactions.
Leucine and niacin interactions
Leucine and niacin/ nicotinic acid (NA) seem to interact with each other to promote fat metabolism. B6 might also have synergistic interaction with leucine. The leucine/NA combination is also found in dietary supplements marketed by NuBio, which initiated this exploration that led us to NuSirt exploration. NuBio to NuTertIngredientsNuSirt, the origin of mixing leucine and… Continue reading Leucine and niacin interactions
Vps34
This post was initiated by a request to take a quick look at a review on the catalytic subunit of the class III phosphoatidylinositol 3-kinase catalytic subunit called vps34 in yeast. [1] The mammalian homolog is coded for by the PIK3c3 gene.
PIKfyve regulation
PIKfyve may be phosphorylated on a number of different, some of which have a regulatory function. This post starts with a quick overview of PIKfyve interacting with the chaperone Vac14 that also binds the phosphatase Fig4. Regulation of PIKfyve is way more complicated that this. One of many phosphorylation sites was chosen for closer examination.