A theme of this post is that B12 (cobalamin Cbl) and and B9/folic acid are partners in many metabolic pathways that involve transfer of single carbons, or methyl groups, from one molecule to another. Cbl and THF are cofactors in pathways involving a mind boggling number of enzymes, any one of which may be inactive… Continue reading B9 and B12
Category: lysosomes
Ivermectin
This post explores several targets of Ivermectin as well as a possible mitophagy inducing agent via targeting P2x7
TREK1
The voltage gated potassium channel binds to and is modulated by the N-terminus of sortilin. Sortilin interacts with the CLCN3 and CLCN5 gene products. What could be the implications for lysomal storage idsorders involving these genes?
CLCN3 gene therapies
This post explores three different strategies to correct defects in two members of the CLCN family of H+/Cl- lysosomal anti porters.
plasmalogen
New research reveals that plasmalogens from mussels may help a neuron like cell line detoxifiy Alzheimer's Disease amyloid-beta peptides. This post also looks at plasmalogen types in meats we eat.