clays and binders, gut health, microbiomes, short chain fatty acids

GPR109a

This post is about GPR109a and the response to LPS. It is a direct full circle to the post called Clinoptilolite that describes a decrease in the tight junction protein ZO-1 in the feces of human endurance atheletes. CLinoptilolite decreases the loss of barrier function. Clinoptilolite cont addresses a metabolomics study demonstrating changes in β-hydroxybutyrate and other metabolites that could be ligands for GPR109a in dairy cows

clays and binders, gut health, short chain fatty acids

Valeric acid esters

his post expands on a very extensive study of broiler chickens conducted by scientists from Belgium and the Netherlands. Part of the motivation of this new supplement was the observation that valeric acid-producing Oscillibacter valericigenes is found to be more abundant in the stools of healthy people as compared to the stools of patients with Crohn's disease. [1] The authors could have done a better job of explaining the role of glucagon like peptide 2. This post is probably also not doing such a good job either. Consult reference [2] for a good review. The major take home of this post is that the L-cells that secrete GLP2 do so by means of G protein coupled receptors of short chain fatty acids. Two of these also bind propionic acid. Another might be more selective for valeric acid.

clays and binders, gut health

clinoptilolite and T cells

This post is a melding of two related papers A 1994 Japanese paper shows activation of T cells by what they call crysotile.  Cystotile is the silicate we commonly call asbestos, [1] A 2004 Croatian paper describes a clinical trial of clinoptilolite, a mineral that contains silica and alumina, on immune cells in immunocompromised participants. [2]

clays and binders, gut health, short chain fatty acids

Clinoptilolite Cont

This investigation was conducted by the School of Veterinary Medicine at the University of Zagreb, Croatia. This study used a total of 16 high-yielding Holstein-Friesian dairy cows averaging 680 ± 30 kg of body weight, between 2–7 years of age. The cows were fed a control diet of haylage, corn silage, and a complete feed mixture with 19% of crude protein. The dietary forage-to-concentrate ratio was5:25 and 60:40