gut health, microbiomes

Urolithin A

The featured image is an attempt to illustrate the experimental cross-over design of this study. Participants were assigned to two groups of 50 each: pomegranate juice or a Mitopure 500 mg tablet of Urolithin A. Blood was drawn followed by a washout period. Then participants crossovered to the other group. Urolithin A, the glucuronidated, and sulfated, metabolites were measured in the blood plasma.

gut health, microbiomes

Mucin and Autism

The featured image is from a 2010 publication by Hansson and Johansson [1] They did not know back then what causes the stratification of the loose layer that bacteria can live in versus the tight, inner layer that excludes bacteria. They did mention the important role of protein thiol disulfide crosslinks. This post will not go into the hypotheses that autism is caused by defects in the mitochondia that can be found in the PubMed literature.What if defects in the mitochondria of the mucus secreting goblet cells can oxidize these all important thiols before they can form the all important disulfides?